Figure 3.

Effect of phosphatase inhibitor cyclosporine (2 μmol/L) on the KCNQ4 current expressed in Xenopus oocytes. (A) The control KCNQ4 currents (upper current traces) were significantly inhibited by the addition of cyclosporine (2 μmol/L; lower current traces). Calibration scale of current traces: 2 s and 1 μA (upper right corner). Calibration scale of voltage step protocol: 2 s and 50 mV (between two current traces). (B) The V_1/2 was shifted significantly to a more positive value after the treatment with cyclosporine (control: • cyclosporine treatment: ○).