Table 3. Estimates of EAC/HGD (RR/OR/HR) in patients with BE for duration response and the numbers for cases/controls.

Author/Year	Case/Control (shorter duration)	RR/OR/HR (95% CI), shorter duration, adjusted	Case/Control (longer duration)	RR/OR/HR (95% CI), longer duration, adjusted
Tsibouris/2004	—	—	14/88	0.51 (0.22–1.19) (daily use>2 years)
Vaughan/2005	—	0.37 (0.15–0.91) (<5 years)	—	0.55 (0.25–1.21) (>5 years)
Nguyen/2009	6/80	0.49 (0.20–1.22) (<36 months)	6/59	0.53 (0.21–1.32) (>36 months)
Nguyen/2010	43/295	0.70 (0.46–1.07) (<12 months)	14/116	0.55 (0.29–1.06) (>12 months)
Kastelein/2011	10/155	0.58 (0.27–1.25) (<2 months)	5/148	0.32 (0.12–0.86) (>2 months)

Abbreviations: BE=Barrett's esophagus; CI=confidence interval; COX=cyclooxygenase; EAC=esophageal adenocarcinoma; HGD=high-grade dysplasia; HR=hazard ratio; OR=odds ratio; RR=relative risk.