Table 2. Univariate and multivariate Cox regression analyses of potential prognostic factors for overall survival.
|
Overall survival |
|||
---|---|---|---|---|
|
Training set |
Validation set |
||
Variable | HR (95% CI) | P | HR (95% CI) | P |
Univariate | ||||
Tumour size |
1.22 (1.12–1.34) |
<0.001 |
1.33 (1.22–1.46) |
<0.001 |
T stage |
|
0.001 |
|
<0.001 |
2 vs 1 |
3.61 (1.56–8.35) |
0.003 |
5.46 (2.01–14.84) |
0.001 |
3 vs 1 |
3.71 (1.81–7.62) |
<0.001 |
4.85 (2.22–10.57) |
<0.001 |
N status (N1 vs N0) |
4.48 (1.06–18.93) |
0.042 |
31.90 (6.87–148.18) |
<0.001 |
M status (M1 vs M0) |
21.21 (4.09–109.93) |
<0.001 |
9.59 (3.18–28.93) |
<0.001 |
TNM stage |
|
<0.001 |
|
<0.001 |
II vs I |
3.39 (1.65–6.96) |
0.001 |
2.84 (1.21–6.64) |
0.016 |
III vs I |
17.69 (6.46–48.43) |
<0.001 |
30.95 (9.42–101.69) |
<0.001 |
IV vs I |
59.07 (10.34–337.40) |
<0.001 |
59.85 (12.65–283.10) |
<0.001 |
Fuhrman grade |
|
<0.001 |
|
<0.001 |
2 vs 1 |
0.65 (0.20–2.12) |
0.470 |
1.01 (0.19–5.22) |
0.994 |
3 vs 1 |
2.74 (1.00–7.50) |
0.049 |
7.18 (1.66–9.31.15) |
0.008 |
4 vs 1 |
8.43 (2.96–24.01) |
<0.001 |
16.09 (3.39–76.43) |
0.005 |
Tumour necrosis | ||||
Present vs absent |
1.97 (1.04–3.71) |
0.037 |
6.22 (2.82–13.74) |
<0.001 |
ECOG-PS (⩾1 vs 0) |
2.21 (1.16–4.22) |
0.016 |
4.40 (2.09–9.25) |
<0.001 |
CXCR4 (high vs low) |
4.32 (1.98–9.42) |
<0.001 |
3.57 (1.69–7.56) |
0.001 |
Multivariate | ||||
Tumour size |
1.03 (0.92–1.16) |
0.588 |
1.06 (0.92–1.21) |
0.409 |
TNM stage | ||||
III+IV vs I+II |
4.96 (1.78–13.84) |
0.002 |
9.06 (2.89–28.37) |
<0.001 |
Fuhrman grade | ||||
3+4 vs 1+2 |
4.16 (1.95–8.87) |
<0.001 |
4.53 (1.71–12.00) |
0.002 |
Tumour necrosis | ||||
Present vs absent |
1.27 (0.57–2.84) |
0.504 |
1.90 (0.71–5.08) |
0.325 |
ECOG-PS (⩾1 vs 0) |
2.11 (1.01–4.40) |
0.047 |
2.76 (1.22–6.26) |
0.015 |
CXCR4 (high vs low) | 3.38 (1.49–7.68) | 0.004 | 2.88 (1.26–6.59) | 0.012 |
Abbreviations: CI=confidence interval; CXCR4=CXC chemokine receptor 4; ECOG-PS=Eastern Cooperative Oncology Group performance status; HR=hazard ratio.