. 2009 Sep 14;30(10):1454–1461. doi: 10.1038/aps.2009.136

Table 2. Significant increase observed for each enzyme activity compared to respective 180-day-old tissue during aging.

	A-SMase	N-SMase	Ac-CDase	N-CDase	Al-CDase	SM synthase	CD synthase
Liver	510 d^-	510 d^-	510 d^b	510 d^-	510 d^-	510 d^-	510 d^c
	720 d^-	720 d^c	720 d^c	720 d^c	720 d^b	720 d^c	720 d^c
Kidney	510 d^-	510 d^-	510 d^c	510 d^b	510 d^-	510 d^-	510 d^-
	720 d^c	720 d^b	720 d^c	720 d^c	720 d^b	720 d^-	720 d^b
Brain	510 d^b	510 d^-	510 d^-	510 d^-	510 d^c	510 d^-	510 d^c
	720 d^c	720 d^-	720 d^c	720 d^c	720 d^c	720 d^c	720 d^c

^bP<0.05, ^cP<0.01 compared to 180-day-tissue activity. “-”, not signifiant. acidic and neutral sphingomyelinases: A-SMase & N-SMase; acidic, neutral, and alkaline ceramidases: Ac-CDase, N-CDase and Al-CDase.