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. 2009 Sep 21;30(10):1385–1391. doi: 10.1038/aps.2009.130

Figure 2.

Figure 2

Effects of intra-DH infusion of D-AP5 or NBQX on the acquisition of conditioned place aversion induced by naloxone-precipitated morphine withdrawal in morphine-treated rats. D-AP5 (5 μg/0.5 μL per side), NBQX (2 μg/0.5 μL per side) or vehicle (0.5 μL/side) was bilaterally microinfused into the dorsal hippocampus 10 min before pairing on the second day of the conditioning session. The columns show the time spent in the drug-paired compartment during the preconditioning (Pre) or testing (test) sessions (A) and the CPA score (B). The CPA score is defined as time in the drug–paired compartment during the testing session minus the time spent during the preconditioning session. Data are expressed as means±SEM. cP<0.01 compared with the corresponding preconditioning session (Student's t test); fP<0.01 compared with vehicle injected rats (one-way ANOVA with Newman-Keuls post hoc test).