Figure 4.

Effects of intra-DH infusion of D-AP5 or NBQX on the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal in morphine-treated rats. D-AP5 (5 μg/0.5 μL per side), NBQX (2 μg/0.5 μL per side) or vehicle (0.5 μL per side) was bilaterally microinfused into the dorsal hippocampus 20 min before the testing session. The columns show the time spent in the drug-paired compartment in the preconditioning (Pre) or testing (test) sessions (A) and the CPA score (B). Data are expressed as means±SEM. ^cP<0.01 compared with the corresponding preconditioning session (Student's t test).