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. 2009 Sep 21;30(10):1392–1398. doi: 10.1038/aps.2009.135

Figure 2.

Figure 2

Atorvastatin suppressed Hcy-induced activation of NADPH oxidase. (A) Hcy (1 mmol/L) increased NADPH oxidase activity in a time-dependent manner. (B) Pretreatment of cells with atorvastatin 30 min prior to 1 mmol/L Hcy abolished NAD(P)H oxidase activation at concentrations of 10 μmol/L and 100 μmol/L. NAD(P)H oxidase activity was assessed as lucigenin-enhanced chemiluminescence using NADPH as a substrate. Results are the means±SD from three independent experiments. cP<0.01 vs untreated cells. eP<0.05, fP<0.01 vs only 1 mmol/L Hcy-treated cells. Ator: atorvastatin; Hcy, homocysteine.