Table 3.
CIN2/CIN3 | Sensitivity (95% CI) | Specificity (95% CI) | AUC | PPV (95% CI) | NPV (95% CI) | Test positivity | |
---|---|---|---|---|---|---|---|
Pap | |||||||
ASCUS+ | 102 | 92.7 (86.3–96.3) | 49.3 (44.0–54.5) | 0.71 | 37.0 (31.5–42.8) | 95.5 (91.3–97.7) | 60.9 |
<ASCUS+ | 8 | ||||||
Pap | |||||||
LSIL+ | 94 | 85.5 (77.7–90.8) | 67.3 (62.2–72.1) | 0.76 | 45.6 (39.0–52.5) | 93.5 (89.7–96.0) | 45.5 |
<LSIL+ | 16 | ||||||
Pap | |||||||
HSIL+ | 79 | 71.8 (62.8–79.4) | 97.1 (94.7–98.4) | 0.85 | 88.8 (80.5–93.8) | 91.5 (88.2–93.9) | 19.6 |
<HSIL+ | 31 | ||||||
VIA | |||||||
Positive | 69 | 62.7 (53.4–71.2) | 65.9 (60.7–70.7) | 0.64 | 37.1 (30.5–44.2) | 84.6 (79.8–88.5) | 41.1 |
Negative | 41 | ||||||
HPV | |||||||
Positive | 92 | 83.6 (75.6–89.4) | 55.7 (50.4–60.9) | 0.70 | 37.7 (31.9–43.9) | 91.4 (86.8–94.5) | 53.9 |
Negative | 18 | ||||||
VIA+HPV | |||||||
Positive | 64 | 58.2 (48.8–67.0) | 83.7 (79.4–87.2) | 0.71 | 53.3 (44.4–62.0) | 86.2 (82.1–89.5) | 26.5 |
Negative | 46 | ||||||
VIA+Pap (ASCUS+) | |||||||
Positive | 66 | 60.0 (50.7–68.7) | 81.9 (77.5–85.6) | 0.71 | 51.6 (43.0–60.1) | 86.5 (82.3–89.8) | 28.3 |
Negative | 44 | ||||||
VIA+Pap (LSIL+) | |||||||
Positive | 64 | 58.2 (48.8–67.0) | 88.0 (84.2–91.1) | 0.73 | 61.0 (51.4–69.7) | 86.8 (82.8–89.9) | 23.2 |
Negative | 46 | ||||||
VIA+Pap (HSIL+) | |||||||
Positive | 56 | 50.9 (41.7–60.1) | 99.1 (97.5–99.7) | 0.75 | 94.9 (86.1–98.3) | 86.3 (82.5–89.3) | 13.0 |
Negative | 54 | ||||||
HPV+Pap (ASCUS+) | |||||||
Positive | 87 | 79.1 (70.6–85.6) | 76.4 (71.6–80.6) | 0.78 | 51.8 (44.3–59.2) | 91.9 (88.2–94.6) | 37.1 |
Negative | 23 | ||||||
HPV+Pap (LSIL+) | |||||||
Positive | 81 | 73.6 (64.7–81.0) | 84.3 (80.0–87.7) | 0.79 | 60.0 (51.6–67.9) | 90.9 (87.2–93.6) | 29.8 |
Negative | 29 | ||||||
HPV+Pap (HSIL+) | |||||||
Positive | 69 | 62.7 (53.4–71.2) | 98.5 (96.6–99.4) | 0.81 | 93.2 (85.1–97.1) | 89.2 (85.7–91.9) | 16.3 |
Negative | 41 | ||||||
VIA or HPV | |||||||
Positive | 97 | 88.2 (80.8–93.0) | 37.9 (32.9–43.1) | 0.63 | 31.3 (26.4–36.7) | 90.9 (85.1–94.6) | 68.4 |
Negative | 13 | ||||||
VIA or Papb | |||||||
Positive | 92 | 83.6 (75.6–89.4) | 63.8 (58.6–68.8) | 0.74 | 42.6 (36.2–49.3) | 92.4 (88.3–95.2) | 47.7 |
Negative | 18 | ||||||
Papb or HPV | |||||||
Positive | 102 | 92.7 (86.3–96.3) | 54.2 (48.9–59.4) | 0.73 | 39.4 (33.6–45.4) | 95.9 (92.1–97.9) | 57.2 |
Negative | 8 |
ASCUS, atypical squamous cells of undetermined significance; AUC, area under the curve; CI, confidence interval; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; NPV, negative predictive value; Pap, Papanicolau; PPV, positive predictive value; VIA, visual inspection with acetic acid. ‘+’ denotes both test positive is positive. ‘or’ denotes either test positive is positive.
Only women with adequate results on all tests included.
Positive Pap smear defined as HSIL+.