Table 5.
Univariate model |
Multivariate modela |
|||
---|---|---|---|---|
Sensitivity of VIA | OR for positive test among CIN2/CIN3 (95% CI) | P | OR for positive test among CIN2/CIN3 (95% CI) | P |
Age ≥40 years | 1.0 | 1.0 | ||
Age <40 years | 4.00 (1.74–9.17) | <0.001 | 3.95 (1.70–9.22) | <0.001 |
CD4+ cell count >350 cells/μl | 1.0 | 1.0 | ||
CD4+ cell count ≤350 cells/μl | 1.87 (0.86–4.09) | 0.1 | 1.75 (0.73–4.20) | 0.2 |
On ART ≥2 years | 1.0 | 1.0 | ||
Off ART | 1.18 (0.43–3.24) | 0.7 | 0.79 (0.26–2.40) | 0.7 |
On ART <2 years | 1.58 (0.65–3.86) | 0.3 | 1.09 (0.40–2.98) | 0.9 |
Univariate model |
Multivariate modela |
|||
---|---|---|---|---|
Specificity of Pap (HSIL+) | OR for negative test among ≤CIN1 (95% CI) | P | OR for negative test among ≤CIN1 (95% CI) | P |
Age ≥40 years | 1.0 | 1.0 | ||
Age <40 years | 4.04 (1.03–15.89) | 0.05 | 3.56 (0.88–14.31) | 0.07 |
CD4+ cell count >350 cells/μl | 1.0 | 1.0 | ||
CD4+ cell count ≤350 cells/μl | 0.33 (0.08–1.29) | 0.1 | 0.33 (0.08–1.37) | 0.1 |
On ART ≥2 years | 1.0 | 1.0 | ||
Off ART | 1.62 (0.31–8.56) | 0.6 | 1.37 (0.25–7.49) | 0.7 |
On ART <2 years | 1.30 (0.30–5.57) | 0.7 | 1.59 (0.35–7.16) | 0.5 |
Univariate model |
Multivariate modela |
|||
---|---|---|---|---|
Specificity of VIA | OR for negative test among ≤CIN1 (95% CI) | P | OR for negative test among ≤CIN1 (95% CI) | P |
Age ≥40 years | 1.0 | 1.0 | ||
Age <40 years | 0.67 (0.42–1.08) | 0.1 | 0.67 (0.41–1.08) | 0.1 |
CD4+ cell count >350 cells/μl | 1.0 | 1.0 | ||
CD4+ cell count ≤350 cells/μl | 0.75 (0.48–1.17) | 0.2 | 0.80 (0.50–1.27) | 0.3 |
On ART ≥2 years | 1.0 | 1.0 | ||
Off ART | 0.73 (0.42–1.30) | 0.3 | 0.80 (0.45–1.42) | 0.8 |
On ART <2 years | 0.51 (0.30–0.87) | 0.01 | 0.55 (0.32–0.94) | 0.03 |
Univariate model |
Multivariate modela |
|||
---|---|---|---|---|
Specificity of HPV | OR for negative test among ≤CIN1 (95% CI) | P | OR for negative test among ≤CIN1 (95% CI) | P |
Age ≥40 years | 1.0 | 1.0 | ||
Age <40 years | 0.54 (0.34–0.84) | 0.006 | 0.51 (0.31–0.81) | 0.005 |
CD4+ cell count >350 cells/μl | 1.0 | 1.0 | ||
CD4+ cell count ≤350 cells/μl | 0.48 (0.31–0.75) | <0.001 | 0.49 (0.31–0.77) | 0.002 |
On ART ≥2 years | 1.0 | 1.0 | ||
Off ART | 0.55 (0.32–0.94) | 0.03 | 0.62 (0.36–1.09) | 0.1 |
On ART <2 years | 0.43 (0.26–0.71) | <0.001 | 0.51 (0.30–0.86) | 0.01 |
ART, antiretroviral therapy; CI, confidence interval; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; OR, odds ratio; VIA, visual inspection with acetic acid.
All covariates listed are included in the multivariate model.