Table 3.
Differentially expressed salivary proteins in BRONJ cases compared to controls in the high BP infusion groups
| Accession Number | Unique Peptides | Protein Name | Fold Change† | P value |
|---|---|---|---|---|
| High BP Infusion BRONJ Group (i117) vs High BP Infusion Control Group (i115) | ||||
| Q53FA3 | 2 | Heat shock 70kDa protein 1-like | ⇑ 4.099 | 8.65E-05 |
| C9JRG0 | 2 | Hemoglobin, delta | ⇑ 3.206 | 6.24E-07 |
| F5H3W7 | 20 | Matrix metallopeptidase 9 | ⇑ 2.903 | 1.95E-04 |
| E7EW61 | 5 | Transthyretin | ⇑ 2.870 | 3.09E-10 |
| P02763 | 9 | Alpha-1-acid glycoprotein 1 | ⇑ 2.848 | 1.90E-05 |
| P14780 | 2 | Matrix metalloproteinase-9 | ⇑ 2.806 | 5.48E-09 |
| P01857 | 23 | Ig gamma-1 chain C region | ⇑ 2.715 | 3.36E-04 |
| P80419 | 2 | Ig heavy chain V-III region GAR | ⇑ 2.656 | 1.98E-05 |
| P05546 | 4 | Heparin cofactor 2 | ⇑ 2.601 | 2.97E-13 |
| P01009-2 | 3 | Isoform 2 of Alpha-1-antitrypsin | ⇑ 2.600 | 6.78E-14 |
| 015144 | 2 | Actin-related protein 2/3 complex subunit 2 | ⇑ 2.361 | 1.39E-14 |
| P29622 | 3 | Kallistatin | ⇑ 2.335 | 3.56E-04 |
| P02652 | 6 | Apolipoprotein A-II | ⇑ 2.285 | 1.90E-05 |
| Q9H9S4 | 2 | Calcium-binding protein 39-like | ⇑ 2.242 | 2.96E-10 |
| P01880 | 2 | Ig delta chain C region | ⇑ 2.148 | 2.89E-15 |
| P63267 | 3 | Actin, gamma-enteric smooth muscle | ⇑ 2.115 | 4.13E-07 |
| P01031 | 4 | Complement C5 | ⇑ 2.104 | 1.44E-15 |
| P35542 | 2 | Serum amyloid A-4 protein | ⇑ 2.102 | 7.91E-04 |
| P04217 | 4 | Alpha-1B-glycoprotein | ⇑ 2.062 | 4.24E-04 |
| P61586 | 2 | Transforming protein RhoA | ⇑ 2.039 | 6.90E-09 |
| P01763 | 2 | Ig heavy chain V-III region WEA | ⇑ 2.034 | 2.16E-07 |
| Q9NUQ9 | 6 | Protein FAM49B | ⇑ 2.002 | 3.98E-05 |
| Q5W0X3 | 2 | FK506 binding protein 1A, 12kDa | ⇑ 1.964 | 8.65E-06 |
| Q15782 | 6 | Chitinase-3-like protein 2 | ⇑ 1.929 | 2.78E-05 |
| P35241 | 3 | Radixin | ⇑ 1.878 | 9.46E-13 |
| P62745 | 2 | Rho-related GTP-binding protein RhoB | ⇑ 1.826 | 2.11E-10 |
| D6RHI9 | 3 | Ribonuclease T2 | ⇑ 1.812 | 4.50E-07 |
| P01770 | 2 | Ig heavy chain V-III region NIE | ⇑ 1.766 | 5.58E-04 |
| P06316 | 2 | Ig lambda chain V-I region BL2 | ⇑ 1.756 | 1.17E-04 |
| P01776 | 2 | Ig heavy chain V-III region WAS | ⇑ 1.738 | 2.77E-04 |
| P00736 | 2 | Complement C1r subcomponent | ⇑ 1.721 | 9.64E-12 |
| B4DJS1 | 3 | cDNA FLJ57383, highly similar to Coronin-1A | ⇑ 1.698 | 1.48E-06 |
| C9JZD1 | 2 | Actin related protein 2/3 complex, subunit 3, 21kDa | ⇑ 1.628 | 3.61E-04 |
| O60888-2 | 2 | Isoform A of Protein CutA | ⇑ 1.620 | 8.97E-07 |
| tr | 2 | Uncharacterized protein OS=Homo sapiens PE=4 SV=1 | ⇑ 1.585 | 7.09E-04 |
| P04430 | 3 | Ig kappa chain V-I region BAN | ⇑ 1.570 | 3.56E-04 |
| P19823 | 4 | Inter-alpha-trypsin inhibitor heavy chain H2 | ⇑ 1.561 | 9.33E-05 |
| B4DTM7 | 6 | cDNA FLJ53006, highly similar to Vinculin | ⇑ 1.555 | 1.08E-04 |
| P0CG05 | 2 | Ig lambda-2 chain C regions | ⇑ 1.546 | 5.51E-06 |
| Q5JZH0 | 2 | Cathepsin A | ⇑ 1.544 | 4.04E-07 |
| F6TTL5 | 2 | Actin-related protein 2/3 complex subunit 4 | ⇑ 1.521 | 4.44E-16 |
| Q86Y46 | 2 | Keratin, type II cytoskeletal 73 | ⇓ 31.745 | 1.46E-10 |
| P13647 | 2 | Keratin, type II cytoskeletal 5 | ⇓ 18.968 | 2.87E-13 |
| C9JKY1 | 11 | Junction plakoglobin | ⇓ 10.649 | 3.68E-05 |
| O75556 | 4 | Mammaglobin-B | ⇓ 7.969 | 3.65E-05 |
| Q5T3N1 | 8 | Annexin A1 | ⇓ 7.875 | 1.85E-04 |
| P04792 | 8 | Heat shock protein beta-1 | ⇓ 6.669 | 2.12E-04 |
| O95171 | 7 | Sciellin | ⇓ 6.573 | 1.32E-12 |
| Q7Z3Z0 | 2 | Keratin, type I cytoskeletal 25 | ⇓ 6.165 | 1.99E-04 |
| P02545 | 7 | Lamin A/C | ⇓ 5.924 | 1.86E-04 |
| Q6ZN66 | 2 | Guanylate-binding protein 6 | ⇓ 5.722 | 7.44E-08 |
| Q96FQ6 | 3 | Protein S100-A16 | ⇓ 5.472 | 5.30E-11 |
| P22735 | 8 | Protein-glutamine gamma-glutamyltransferase K | ⇓ 4.374 | 9.85E-04 |
| P62851 | 3 | 40S ribosomal protein S25 | ⇓ 4.158 | 3.64E-10 |
| B4DJ43 | 3 | cDNA FLJ53341, highly similar to Tubulin beta-4 chain | ⇓ 3.325 | 1.11E-15 |
| P25705 | 3 | ATP synthase subunit alpha, mitochondrial | ⇓ 3.091 | 1.32E-06 |
| Q5SQY1 | 3 | Novel protein similar to beta-tubulin 4Q | ⇓ 3.070 | 3.09E-05 |
| P63241-2 | 3 | Isoform 2 of Eukaryotic translation initiation factor 5A-1 | ⇓ 3.034 | 9.12E-04 |
| P25398 | 4 | 40S ribosomal protein S12 | ⇓ 2.833 | 5.79E-06 |
| P68104 | 3 | Elongation factor 1-alpha 1 | ⇓ 2.801 | 1.06E-07 |
| P61026 | 3 | Ras-related protein Rab-10 | ⇓ 2.731 | 1.08E-05 |
| O60218 | 6 | Aldo-keto reductase family 1 member B10 | ⇓ 2.605 | 9.68E-06 |
| B4DPU3 | 4 | cDNA FLJ56548, highly similar to Elongation factor 2 | ⇓ 2.566 | 4.55E-12 |
| A8K2U0 | 11 | Alpha-2-macroglobulin-like protein 1 | ⇓ 2.522 | 3.61E-04 |
| Q9NZT1 | 7 | Calmodulin-like protein 5 | ⇓ 2.488 | 6.82E-04 |
| P07951 | 3 | Tropomyosin 2 (Beta) | ⇓ 2.314 | 7.67E-04 |
| P30838 | 2 | Aldehyde dehydrogenase, dimeric NADP-preferring | ⇓ 2.049 | 1.40E-10 |
| B4DLA9 | 2 | Histone H2B | ⇓ 2.018 | 1.64E-13 |
| P29373 | 2 | Cellular retinoic acid binding protein 2 | ⇓ 1.997 | 3.27E-09 |
| Q6LES2 | 4 | Annexin | ⇓ 1.984 | 4.06E-04 |
| Q5JR95 | 2 | Ribosomal protein S8 | ⇓ 1.978 | 2.93E-04 |
| ALDH3A1 | 4 | ldehyde dehydrogenase, dimeric NADP-preferring | ⇓ 1.940 | 1.36E-10 |
| P05120 | 3 | Plasminogen activator inhibitor 2 | ⇓ 1.894 | 2.05E-10 |
| Q9Y2V2 | 2 | Calcium-regulated heat stable protein 1 | ⇓ 1.792 | 1.36E-11 |
| P50990 | 3 | T-complex protein 1 subunit theta | ⇓ 1.729 | 1.91E-10 |
| P08493 | 2 | Matrix Gla protein | ⇓ 1.699 | 3.08E-08 |
| 075390 | 3 | Citrate synthase, mitochondrial | ⇓ 1.516 | 2.06E-07 |
†
⇑ Represents upregulation and ⇓ Represents downregulation