Table 4.
Differentially expressed salivary proteins in low BP infusion BRONJ group compared to high BP infusion control group
| Accession Number | Unique Peptides | Protein Name | Fold Change† | P value |
|---|---|---|---|---|
| Low BP Infusion BRONJ Group (i116) vs High BP Infusion Control Group (i115) | ||||
| Q86Y46 | 2 | Keratin, type II cytoskeletal 73 | ⇓ 6.554 | 2.11E-15 |
| P02538 | 28 | Keratin, type II cytoskeletal 6A | ⇓ 6.022 | 1.02E-07 |
| P13646 | 50 | Keratin, type I cytoskeletal 13 | ⇓ 5.558 | 6.80E-07 |
| P12035 | 10 | Keratin, type II cytoskeletal 3 | ⇓ 5.302 | 1.20E-07 |
| B4DRW1 | 40 | DNA FLJ55805, highly similar to Keratin, type II cytoskeletal 4 | ⇓ 5.222 | 3.23E-05 |
| P14923 | 11 | Junction plakoglobin | ⇓ 5.001 | 3.44E-15 |
| P08727 | 8 | Keratin, type I cytoskeletal 19 | ⇓ 4.861 | 2.94E-05 |
| Q01546 | 11 | Keratin, type II cytoskeletal 2 oral | ⇓ 4.850 | 1.60E-06 |
| P08779 | 40 | Keratin, type I cytoskeletal 16 | ⇓ 4.632 | 8.83E-05 |
| P47929 | 6 | Galectin-7 | ⇓ 4.624 | 8.57E-06 |
| P19012 | 2 | Keratin, type I cytoskeletal 15 | ⇓ 4.453 | 1.55E-15 |
| Q5T3N1 | 8 | Annexin | ⇓ 4.438 | 3.56E-07 |
| P07355 | 8 | Annexin A2 | ⇓ 4.307 | 7.90E-08 |
| P13647 | 11 | Keratin, type II cytoskeletal 5 | ⇓ 4.090 | 4.62E-04 |
| Q9HCY8 | 6 | Protein S100-A14 | ⇓ 4.050 | 7.72E-07 |
| Q8N1N4 | 14 | Keratin, type II cytoskeletal 78 | ⇓ 4.035 | 3.74E-05 |
| P15924 | 43 | Desmoplakin | ⇓ 3.942 | 1.38E-04 |
| P02533 | 10 | Keratin, type I cytoskeletal 14 | ⇓ 3.803 | 9.50E-04 |
| Q7Z3Z0 | 2 | Keratin, type I cytoskeletal 25 | ⇓ 3.782 | 2.11E-15 |
| Q13835 | 12 | Plakophilin-1 | ⇓ 3.751 | 1.59E-05 |
| P04083 | 14 | Annexin A1 | ⇓ 3.544 | 2.76E-04 |
| P04792 | 8 | Heat shock protein beta-1 | ⇓ 3.477 | 2.77E-11 |
| P20930 | 2 | Filaggrin | ⇓ 3.431 | 3.03E-14 |
| B4DLA9 | 2 | Histone H2B type 2-F | ⇓ 3.332 | 2.89E-15 |
| P22735 | 8 | Protein-glutamine gamma-glutamyltransferase K | ⇓ 3.330 | 1.99E-12 |
| O60437 | 39 | Periplakin | ⇓ 3.283 | 3.70E-05 |
| Q92817 | 23 | Envoplakin | ⇓ 3.129 | 3.82E-06 |
| Q6ZN66 | 9 | Guanylate-binding protein 6 | ⇓ 3.061 | 2.48E-07 |
| P62851 | 3 | 40S ribosomal protein S25 | ⇓ 3.041 | 3.99E-14 |
| Q9UBG3 | 9 | Cornulin | ⇓ 3.029 | 7.81E-05 |
| P19013 | 3 | Keratin, type II cytoskeletal 4 | ⇓ 2.821 | 7.85E-04 |
| B4DQ53 | 6 | cDNA FLJ51275 | ⇓ 2.690 | 2.16E-06 |
| B4DPU3 | 4 | cDNA FLJ56548, highly similar to Elongation factor 2 | ⇓ 2.642 | 6.11E-15 |
| P05388 | 3 | 60S acidic ribosomal protein P0 | ⇓ 2.618 | 5.69E-06 |
| P63241 | 3 | Eukaryotic translation initiation factor 5A-1 | ⇓ 2.605 | 3.89E-15 |
| Q96QV6 | 3 | Histone H2A type 1-A | ⇓ 2.580 | 5.75E-12 |
| Q9H4B7 | 4 | Tubulin beta-1 chain | ⇓ 2.553 | 3.97E-04 |
| Q16778 | 9 | Histone H2B type 2-E | ⇓ 2.543 | 8.52E-06 |
| Q5JR95 | 2 | 40S ribosomal protein S8 | ⇓ 2.530 | 1.52E-06 |
| Q5SQY1 | 3 | Novel protein similar to beta-tubulin 4Q | ⇓ 2.472 | 8.29E-14 |
| O75367 | 3 | Core histone macro-H2A.1 | ⇓ 2.405 | 9.82E-08 |
| Q59GP5 | 3 | Eukaryotic translation elongation factor 1 alpha 2 variant | ⇓ 2.405 | 6.65E-05 |
| P01040 | 8 | Cystatin-A | ⇓ 2.321 | 1.97E-05 |
| P08238 | 17 | Heat shock protein HSP 90-beta | ⇓ 2.250 | 6.54E-10 |
| P31947 | 18 | Epithelial cell marker protein 1 | ⇓ 2.240 | 6.99E-15 |
| P16401 | 4 | Histone H1.5 | ⇓ 2.193 | 4.39E-08 |
| Q16695 | 3 | Histone H3.1t | ⇓ 2.181 | 6.89E-08 |
| P15515 | 6 | Histatin-1 | ⇓ 2.158 | 5.53E-05 |
| P14555 | 3 | Phospholipase A2, membrane associated | ⇓ 2.134 | 1.43E-14 |
| P50990 | 3 | T-complex protein 1 subunit theta | ⇓ 2.132 | 1.55E-15 |
| O15335 | 2 | Chondroadherin | ⇓ 2.112 | 1.82E-14 |
| Q16610 | 5 | Extracellular matrix protein 1 | ⇓ 2.091 | 6.00E-10 |
| Q08188 | 26 | Protein-glutamine gamma-glutamyltransferase E | ⇓ 2.090 | 2.09E-04 |
| P07476 | 18 | Involucrin | ⇓ 2.057 | 2.55E-06 |
| P62805 | 10 | Histone H4 | ⇓ 2.050 | 2.96E-08 |
| P55072 | 10 | Transitional endoplasmic reticulum ATPase | ⇓ 2.035 | 3.25E-11 |
| P25398 | 4 | 40S ribosomal protein S12 | ⇓ 1.975 | 4.44E-16 |
| P13645 | 24 | Keratin, type I cytoskeletal 10 | ⇓ 1.974 | 3.20E-04 |
| P48643 | 3 | T-complex protein 1 subunit epsilon | ⇓ 1.913 | 6.05E-07 |
| P49189 | 3 | 4-trimethylaminobutyraldehyde dehydrogenase | ⇓ 1.897 | 3.71E-04 |
| Q15149 | 4 | Plectin | ⇓ 1.896 | 1.78E-15 |
| Q00610 | 7 | Clathrin heavy chain 1 | ⇓ 1.892 | 3.09E-05 |
| P07951 | 3 | Tropomyosin beta chain | ⇓ 1.886 | 6.40E-06 |
| P63104 | 10 | Protein kinase C inhibitor protein 1 | ⇓ 1.882 | 8.76E-10 |
| P07900 | 5 | Heat shock protein HSP 90-alpha | ⇓ 1.871 | 4.96E-06 |
| Q15366 | 2 | Poly (rC)-binding protein 2 | ⇓ 1.862 | 2.79E-09 |
| P40394 | 4 | Alcohol dehydrogenase class 4 mu/sigma chain | ⇓ 1.809 | 3.25E-04 |
| P30838 | 7 | Aldehyde dehydrogenase, dimeric NADP-preferring | ⇓ 1.808 | 7.64E-07 |
| P13489 | 5 | Ribonuclease inhibitor | ⇓ 1.803 | 9.43E-08 |
| P07384 | 2 | Calpain-1 catalytic subunit | ⇓ 1.791 | 4.00E-15 |
| P46940 | 19 | Ras GTPase-activating-like protein IQGAP1 | ⇓ 1.791 | 5.10E-06 |
| Q7Z406 | 4 | Myosin-14 | ⇓ 1.751 | 7.46E-14 |
| A8K2U0 | 11 | Alpha-2-macroglobulin-like protein 1 | ⇓ 1.749 | 1.23E-10 |
| P13797 | 6 | Plastin-3 | ⇓ 1.689 | 2.11E-05 |
| P35579 | 52 | Myosin-9 | ⇓ 1.689 | 7.61E-06 |
| B4DTG2 | 5 | Elongation factor 1-gamma | ⇓ 1.676 | 5.69E-07 |
| P17858 | 5 | 6-phosphofructokinase, liver type | ⇓ 1.667 | 5.46E-06 |
| P06576 | 11 | ATP synthase subunit beta, mitochondrial | ⇓ 1.667 | 2.78E-04 |
| Q15084 | 5 | Protein disulfide-isomerase A6 | ⇓ 1.654 | 2.76E-06 |
| P36952 | 6 | Serpin B5 | ⇓ 1.651 | 5.93E-07 |
| P07384 | 7 | Calpain-1 catalytic subunit | ⇓ 1.650 | 1.33E-05 |
| Q16851 | 6 | UTP--glucose-1-phosphate uridylyltransferase | ⇓ 1.634 | 2.35E-07 |
| P14625 | 3 | Endoplasmin | ⇓ 1.615 | 6.29E-04 |
| P09525 | 4 | Annexin A4 | ⇓ 1.606 | 2.22E-14 |
| P10809 | 3 | 60 kDa heat shock protein, mitochondrial | ⇓ 1.594 | 2.07E-11 |
| P60660 | 8 | Myosin light polypeptide 6 | ⇓ 1.585 | 2.84E-09 |
| Q9UHA7 | 7 | Interleukin-36 alpha | ⇓ 1.569 | 2.18E-04 |
| Q9Y2V2 | 2 | Calcium-regulated heat stable protein 1 | ⇓ 1.564 | 6.00E-15 |
| P13693 | 2 | Translationally-controlled tumor protein | ⇓ 1.526 | 1.66E-07 |
| Q7L7L0 | 4 | Histone H2A type 3 | ⇓ 1.519 | 4.72E-04 |
| Q06830 | 8 | Peroxiredoxin-1 | ⇓ 1.519 | 5.99E-04 |
| P62879 | 2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | ⇓ 1.517 | 2.98E-10 |
| P30041 | 10 | Peroxiredoxin-6 | ⇓ 1.503 | 1.13E-07 |
†
⇑ Represents upregulation and ⇓ Represents downregulation