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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Oct 31;1843(8):1674–1686. doi: 10.1016/j.bbamcr.2013.10.019

Figure 6. Impact of signal peptides and post-translational modifications on trafficking through the general Sec or aSec system.

Figure 6

A signal sequence with a relatively strong Sec avoidance motif is indicated in cyan, and signal sequences that can support transport by the general Sec system are indicated in red. A: In most streptococci, the aSec locus encodes four or more putative glycosyl transferases, and the SRR glycoprotein signal peptide is not optimal for general Sec transport. B: GspB variants with one or more substitutions of critical glycine residues in the signal peptide H region, or wild-type Fap1, may be inefficiently transported by the general Sec system (dashed line indicates transport of partially or incorrectly glycosylated substrates). C: In staphylococci, the aSec locus includes just the core GtfA/B glycosyl transferase, and the SRR glycoprotein signal peptide can facilitate transport via either the Sec or aSec pathway.