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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Oct 31;1843(8):1674–1686. doi: 10.1016/j.bbamcr.2013.10.019

Figure 8. Model for SRR glycoprotein biogenesis.

Figure 8

A: A partially glycosylated preprotein arrives at the translocon, and one or more of the Asps facilitate an interaction between SecA2 and the preprotein AST domain that trigger opening of the SecY2 channel. B: An Asp123 complex further modifies the glycan composition as translocation of the SRR glycoprotein proceeds through SecA2/Y2. The Asp123 modifications could include trimming, replacement, or addition of carbohydrate moieties. SecA2 and SecY2 are thought not to have a direct enzymatic role in glycan modification, but instead facilitate the interaction between the Asp complex and the substrates.