Table 4.
BIOCHEMICAL BIOMARKERS OF Mn-INDUCED NEUROTOXICITY
| Study | Study Population | Alterations in the exposed population |
|---|---|---|
|
| ||
| Ai et al. (1998) | Male welders (n=39), control group: non-occupationally exposed to Mn (n=19) | Incr HVA and Incr VMA (sig) |
| Siqueira and Moraes (1989) | Male workers occupationally exposed to Mn in a ferromanganese alloy plant (n=40), control group: non-occupationally exposed to Mn (n=25) | HVA levels not sig. different among the groups |
| Montes et al. (2008) | Population living close to a mine and mineral processing plant in Mexico (n=300) | Positive correl. (sig) prolactin and WB Mn |
| Alessio et al. (1989) | Male workers employed in a ferrous-Mn foundry (n=14), control group: non-occupationally exposed to Mn (n=14) | Incr Prolactin (sig) |
| Buchet (1993) | Male workers exposed to Mn-containing dust in a dry alkaline battery plant or an Mn oxide and salt producing plant (n=68), control group: non-occupationally exposed to Mn (n=35) | Positive correl. (sig) HVA and urine Mn |
| Roels et al. (1992) | Male workers (n=92) in a dry alkaline factory, exposed to MnO2, control group: non-occupationally exposed to Mn (n=101) | Incr Prolactin (not sig) |
| Takser et al. (2004) | Pregnant women at delivery (n=87) | Positive correl. (sig) prolactin and Mn cord blood levels |
Sig - significant, correl-correlation; incr - increased; Decr - decreased