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. 2014 Mar 13;7(5):525–534. doi: 10.1242/dmm.015040

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4 — Ectopic Runx2 inhibits ELF5 and p-STAT5 during lactation. (A) Prolactin receptor (Prlr) mRNA expression at pregnancy (d8P, d17P) and lactation (d1L) in Runx2 and WT glands; data are means ± s.d., normalised to HPRT and relative to WT virgin. (B) ELF5 and p-STAT5 protein levels are not affected in MMTV-Runx2 glands at late pregnancy (day 17) but, during lactation, Runx2 overexpression causes a reduction in levels of ELF5 and p-STAT5 (C). Each image is representative of n≥3 mice. Boxed areas are shown at higher magnification. Scale bars: 10 μm (5 μm in higher-magnification images).