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. 2014 Mar 13;7(5):561–569. doi: 10.1242/dmm.013813

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7 — Untagged Q49X failed to establish functional gap-junction coupling and dominantly inhibited the coupling of co-expressed Cx40 or Cx43 in N2A cells. (A) N2A cell pairs expressing Q49X-IRES-GFP exhibited no coupling (G_j=0 nS), unlike cell pairs expressing Cx40-IRES-GFP (***P<0.001). (B) Cell pairs co-expressing Q49X-IRES-GFP and Cx40-RFP exhibited significantly lower G_j (***P<0.001) compared with the cell pairs co-expressing Cx40-IRES-GFP and Cx40-RFP. (C) Cell pairs co-expressing Q49X-IRES-GFP and Cx43-RFP exhibited a significantly lower G_j (***P<0.001) than that obtained from the cell pairs co-expressing Cx40-IRES-GFP and Cx43-RFP. Number of cell pairs tested in each case is indicated.