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Increase in bone-marrow fat content in Wrn−/−Terc−/− mutants. Adipocyte volume was measured in WT, Wrn−/−, Terc−/− and Wrn−/−Terc−/− femurs from young and aged animals. Data represent average ± s.e.m. Statistical significance is ****P<0.0001 or *P<0.05 compared with young WT (n=5 per group).
