Table 3. Mutations in the EGFR Pathway Genes and SMAD4 in Intestinal- and Pancreatobiliary-Tyoe Ampullary Carcinoma.
| KRAS codon12 |
KRAS codon13 |
KRAS codon61 |
BRAF | PIK3CA | KRAS +PIK3CA |
KRAS +SMAD4 |
KRAS +PIK3CA +SMAD4 |
Total (%) |
|
|---|---|---|---|---|---|---|---|---|---|
| Intestinal (n=25) | 8 | 0 | 0 | 0 | 2 | 2 | 2* | 1 | 15 (60) |
|
Pancreatobiliary
(n=24) |
7 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 12 (50) |
|
Signet ring cell
(n=1) |
1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (100) |
|
Adenosquamous
(n=1) |
1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (100) |
|
Undifferentiated
(n=1) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 (0) |
| Total | 17 | 0 | 3 | 1 | 3 | 2 | 2 | 1 | 29 |
*
: One of KRAS mutation was in codon 13.
Abbreviations: EGFR – epidermal growth factor receptor