Table 2.
Ethanol intakes of adult and peri-adolescent P, HAD1, and HAD2 rats under 24-h free-choice access conditions
| Conditions | Ethanol Intakes and Blood Ethanol Levels (BELs) | Reference |
|---|---|---|
| Adult male P rats; 10% ethanol vs. water; monitored pattern of ethanol intake | ~7 g ethanol/kg/day; multiple bout drinking of 1–1.5 g/h; ~70% ethanol intake in dark phase; BELs averaged 45–90 mg% during dark phase | Murphy et al., 1986 |
| Adult male P rats; 24-h operant with escalating 2% to 30%; ethanol (FR5) vs. water | Greatest intake at 15%, ~8 g/kg/day; average intake ~6 g/kg/day | Murphy et al., 1989 |
| Adult male P rats; male HAD1 rats; male HAD2 rats; 10% ethanol vs. water | ~6 g/kg/day for P and HAD1 rats; ~5 g/kg/day for HAD2 rats | Samson et al., 1998 |
| Adult male P rats; male HAD1 rats; male HAD2 rats; 24-h 2-lever operant; 10% ethanol (FR1) vs. water (FR1) | ~3.5 g/kg/day for P rats; ~4.5 g/kg/day for HAD1 rats; ~6.5 g/kg/day for HAD2 rats; ~11 ethanol bouts/day for HAD1 rats; ~16 ethanol bouts/day for P rats; ~22 ethanol bouts/day for HAD2 rats | Files et al., 1998 |
| Male & female peri-adolescent P rats; 15% ethanol vs. water; concurrent 10, 20, & 30% ethanol vs. water | With single ethanol concentration ~6 g/kg/day; with multiple ethanol concentrations ~10 g/kg/day | Bell et al., 2003 |
| Male & female peri-adolescent HAD1 & HAD2 rats; 15% ethanol vs. water; concurrent 10, 20, & 30% ethanol vs. water | With single ethanol concentration ~5 g/kg/day; with multiple ethanol concentrations ~7 g/kg/day; no significant sex or line differences | Bell et al., 2004 |
| Male & female adult & peri- adolescent P rats; 15% ethanol vs. water; monitored pattern of drinking | Adult & peri-adolescent intakes 6–8 g/kg/day; majority occurred during dark phase; BELs at end of dark phase were 40–60 mg% | Bell et al., 2006b |
| Adult male P rats; 20% ethanol vs. water; intermittent access (MWF) | Peak at ~6.5 g/kg/day; ~40 mg% at 45 min into dark phase | Simms et al., 2008 |
| Male & female adult & peri- adolescent HAD1 & HAD2 rats; 15% ethanol vs. water; monitored pattern of drinking | Adult & peri-adolescent HAD1 intakes 6–8 g/kg/day; HAD2 intakes ~6 g/kg/day except for male adolescent HAD2 intakes ~9 g/kg/day; most ethanol drinking occurred during the dark phase | Dhaher et al., 2012 |