Table 3.
Ethanol intakes of adult P, HAD1 and HAD2 rats under scheduled access conditions
| Conditions | Ethanol intakes and BELs | Reference |
|---|---|---|
| Adult male P rats; 4h access; dark phase; 10% ethanol vs. water; time-course BELs | ~2 g/kg/session with most consumed within first 15-min; BELs peaked at ~120 mg% 1h into the session | Murphy et al., 1986 |
| Adult male P & HAD rats; 4h access; dark phase; 10% ethanol vs. 0.0125% saccharin | ~2 g/kg/session for P rats & ~3 g/kg/session for HAD rats; major bout of ethanol drinking for both lines occurred within first 15-min; majority of saccharin intake occurred after 1st h | Russell et al., 1996 |
| Adult female P rats; 4h access; dark phase; 10% ethanol vs. water | 2–3 g/kg/session | McKinzie et al., 1998a |
| Adult male P rats; 4h access; dark phase; 2-lever operant; 15% ethanol (FR5) vs. water (FR1) | ~2 g/kg/session most consumed in 1st 30-min | McKinzie et al., 1998b |
| Adult male P rats; male HAD1 rats; male HAD2 rats; 30-min access; 2-lever operant; 10% ethanol (FR1) vs. water (FR1) | ~0.25 g/kg/30-min for P rats; ~0.65 g/kg/30-min for HAD1 rats; ~0.25 g/kg/30-min for HAD2 rats | Files et al., 1998 |
| Adult female P rats; 2h access; dark phase; 10% ethanol vs. water; 2h operant, 10% ethanol (FR1) & 0.0125% saccharin (FR1) | ~2 g/kg/session most consumed in 1st 15-min; ~17 ml saccharin/session most consumed after 30-min; ~120 ethanol responses/session most in 1st 20-min; ~110 saccharin responses/session most in 1st 40-min | Nowak et al., 1999 |
| Adult male P, adult male HAD1, adult male HAD2; 20-min appetitive & 20-min consummatory sessions; 10% ethanol; light phase | 1 to 1.5 g/kg/20-min with no line differences in intake | Czachowski & Samson, 2002 |
| Adult male P rats; 1h access; dark phase; 2-lever operant; 15% ethanol (FR5) vs. water (FR1) | ~1.3 g/kg/session | Rodd et al., 2003 |
| Adult male HAD1 & HAD2 rats; 1h access; dark phase; 2-lever operant; 15% ethanol (FR5) vs. water (FR1) | HAD1 intakes ~1.2 g/kg/session; HAD2 intakes ~1.6 g/kg/session | Oster et al., 2006 |
| Adult male P rats; 1h access; dark phase; 2-lever operant; 15% ethanol (FR5) vs. 0.0125% saccharin (FR1) | ~1.2 to 1.4 g/kg/session; ~300 ethanol responses/session; ~20 saccharin responses/session | Toalston et al., 2008 |
| Adult female P rats; 1h access; dark phase; 3-lever operant; concurrent 10, 20 & 30% ethanol each containing 0.14 mg/ml nicotine (FR5) with water freely available | ~2 g/kg/session & 2 mg nicotine/kg/session; ~80 mg% BELs & ~50 ng/ml blood nicotine levels | Hauser et al., 2012 |