Table 4.
Ethanol intakes and BELs of P rats under multiple scheduled access conditions
Conditions | Ethanol intakes and BELs | Reference |
---|---|---|
Adult male P rats; 4 × 1-h access across dark phase; 1 × 4-h access during early dark phase; 10% ethanol vs. water | ~1 g/kg/1-h session; average BELs ~40 to 80 mg% (range 0 to 152 mg%) at the end of each session; ~2 g/kg/4-h session most of it in the 1st 15 min; average BEL at 1 h ~120 mg% (range 42 to 178 mg%) at 3.5 h ~50 mg% | Murphy et al., 1986 |
Adult male P rats; 3 × 1-h access across dark phase; concurrent 15 & 30% ethanol vs. water | ~2 g/kg/session; BELs ~80 mg% | Bell et al., 2006a |
Male & female adult & peri- adolescent P rats; 3 × 1-h access across dark phase; concurrent 15 & 30% ethanol vs. water | Peri-adolescent female intakes ~10 g/kg/d, adult female intakes ~7 g/kg/d, adolescent male intakes ~6 g/kg/d, and adult male intakes ~5 g/kg/d; adolescent male BEL levels ~60 mg% at 15 min, ~100 mg% at 30 min, ~80 mg% at 45 min and ~100 mg% at 60 min; adult female BEL ~75 mg% at 60 min; peri-adolescent female BEL ~90 mg% at 30 min | Bell et al., 2011 |
Adult female P rats; 4 × 1-h access across dark phase; 3-lever operant; concurrent 10, 20, & 30% ethanol (FR5) with ad libitum water | Ethanol intakes were 1.2–1.7 g/kg/session; BELs ~125 mg% after 1st session; ~175 mg% after 2nd session; ~130 mg% before 3rd session; ~235 mg% after 4th session | McBride et al., 2013a |