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Pde1, but not Pde2, is required for regulation of cAMP levels. A and B, impacts of C. neoformans var. neoformans PDE1 and PDE2 gene disruptions on melanin and capsule formation (cAMP signaling). Cells were spotted on Niger seed agar for melanin and inoculated in DMEM for capsule induction for 3 days at 30 °C, respectively. C, cAMP assay suggests that Pde1, but Pde2, affects cAMP accumulation. Each cAMP level represents the value estimated from 1 × 106 cells.
