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Ras1 regulates the Cac1-cAMP signaling pathway in C. neoformans. The Ras1 function opposes that of Gpr4/Gpa1. Gpa1, G protein α subunit (8, 62); Gpg1/2, G protein γ subunits 1 and 2 (11); Crg2, cryptococcal regulator of G protein signaling 2 (39, 63); Pkr1 and Pka1, cAMP-dependent protein kinase regulatory and catalytic subunit, respectively (14). TFs denote Nrg1 (60) and other unknown transcriptional factors.
