FIGURE 2.

Analysis of pathways for biosynthesis of FeS clusters, the molybdenum cofactor (Moco), thiamine, and 2-thiouridine in A. vinosum as predicted from the genome sequence and the transcription patterns of the respective genes. The transcriptomic profiles are depicted next to the respective protein and are color-coded; relative -fold changes in mRNA levels >2 (green) were considered significantly enhanced. Relative changes <0.5 (red) were considered as indicating significant decreases in mRNA levels. Relative -fold changes between 0.5 and 2 (yellow) indicated unchanged mRNA levels. For rhd_2599, tusA, and dsrE2, the results obtained via qRT-PCR in this study (values taken from the experiments presented in Fig. 1) are depicted in cycles. Administered sulfur compounds from left to right: sulfide, thiosulfate, elemental sulfur, and sulfite. In the figure DsrC/TusE proteins without any cysteine residues are omitted. cPMP, cyclic pyranopterin monophosphate; MPT, molybdopterin; bis-MGD, bis-molybdopterin-guanine-dinucleotide cofactor.