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. 2014 Mar 13;289(18):12435–12445. doi: 10.1074/jbc.M114.562587

FIGURE 7.

FIGURE 7.

CaMKII activity increases β-cell action potential firing frequency. A, control β-cell electrical activity in response to 14 mm glucose. Inset shows the APs from the segment of activity indicated by the horizontal gray bar. B, electrical activity from a β-cell expressing EAC3I in response to 14 mm glucose. Inset shows the APs from the segment of activity indicated by the horizontal gray bar. C, control β-cell electrical activity in response to glucose (14 mm) and tolbutamide (200 μm). D, electrical activity from a β-cell expressing EAC3I in response to glucose (14 mm) and tolbutamide (200 μm). E, β-cell action potential firing frequency 10 min post glucose (14 mm) treatment, rtTA (n = 16) and EAC3I (n = 15). F, β-cell action potential firing frequency 10 min post glucose (14 mm) and 2 min post glucose (14 mm) with tolbutamide (200 μm) treatment, rtTA (n = 7) and EAC3I (n = 9). Error bars represent means ± S.E.; *, p < 0.05.