TABLE 2.

Pathway annotation by DAVID

Pathways	Genes	p Value
KEGG database
Pathways in cancer	E2F1, AR, RXRA, PPARG, TP53, FOXO1, NFKB1, RB1, STAT1, STAT3, FOS, HDAC2, EP300, HIF1A, ETS1, JUN, MYC	2.24E-09
Prostate cancer	E2F1, AR, ATF4, EP300, CREB1, TP53, FOXO1, NFKB1, RB1	4.65E-07
Cell cycle	E2F1, RAD21, EP300, HDAC2, E2F4, TP53, RB1, MYC, SMC3	6.24E-06
Huntington disease	SIN3A, EP300, HDAC2, SP1, CREB1, PPARG, TP53, TBP, PPARGC1A	8.87E-05
Pancreatic cancer	E2F1, TP53, NFKB1, RB1, STAT1, STAT3	2.80E-04
Chronic myeloid leukemia	E2F1, HDAC2, TP53, NFKB1, RB1, MYC	3.39E-04
Small cell lung cancer	E2F1, RXRA, TP53, NFKB1, RB1, MYC	5.74E-04
Maturity onset diabetes of young	HNF1A, HNF4A, FOXA2, HNF4G	0.0011
Thyroid cancer	RXRA, PPARG, TP53, MYC	0.0016
Adipocytokine signaling pathway	PPARA, RXRA, NFKB1, PPARGC1A, STAT3	0.0021
Bladder cancer	E2F1, TP53, RB1, MYC	0.0048
MAPK signaling	FOS, ATF4, JUN, JUND, TP53, NFKB1, SRF, MYC	0.0056
Non-small cell lung cancer	E2F1, RXRA, TP53, RB1	0.0097
BioCarta database
METS effect on macrophage differentiation	E2F1, FOS, SIN3A, HDAC2, E2F4, ETS1, JUN	3.22E-06
CARM1 and regulation of the estrogen receptor	EP300, HDAC2, GTF2F1, ESR1, TBP, PPARGC1A, BRCA1	5.82E-05
Mechanism of gene regulation by peroxisome proliferators via PPAR	PPARα, EP300, SP1, JUN, RXRA, RB1, PPARγC1A	0.0012
Role of PPAR-γ coactivators in obesity and thermogenesis	EP300, RXRA, PPARG, PPARGC1A	0.0019
Oxidative stress-induced gene expression via Nrf2	MAFF, FOS, JUN, CREB1, MAFK	0.0019
IL-6 signaling pathway	FOS, CEBPB, JUN, SRF, STAT3	0.0019
PDGF signaling pathway	FOS, JUN, STAT1, SRF, STAT3	0.0056
EGF signaling pathway	FOS, JUN, STAT1, SRF, STAT3	0.0064
Human cytomegalovirus and map kinase pathways	SP1, CREB1, NFKB1, RB1	0.0072
Hypoxia-inducible factor in the cardiovascular system	HIF1A, EP300, JUN, CREB1	0.0088