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Functional domains and regulation of Gdown1 by phosphorylation. Gdown1 blocks TTF2 with the NTD and blocks TFIIF with the CTD. A, during interphase unmodified Gdown1 binds to Pol II tightly and strongly inhibits both TFIIF and TTF2. B, during mitosis Gdown1 is phosphorylated on Ser-270, and this reduces the affinity of Gdown1 for Pol II and allows TFIIF and TTF2 to function on Pol II.
