Table 4. Association of the three SNPs of VDR gene with phenotypic values in sons from one offsping (mean±SD, n=400). Values for BMD are raw values (means±SD); P values are results of analysis of variance (ANOVA) test for the least square mean of BMD among various genotypes after adjusting for significant covariates of age, weight, and height. P values are results of ANOVA test for the lease square mean of BMI, fat mass, lean mass among various genotypes after adjusting for significant covariates of age. Bold indicates significant P values (P<0.05). cP<0.01 vs AG genotype. fP<0.01 vs GG genotype..
| Geno-type | n | Age (years) | Height (cm) | Weight (kg) | BMI | Lumber spine BMD (g/cm2) | Femoral neck BMD (g/cm2) | Total hip BMD (g/cm2) | Fat mass (kg) | Lean mass (kg) | PFM (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ApaI | |||||||||||
| AA | 36 | 29.5±6.0 | 172.0±6.3 | 70.9±11.1 | 23.9±3.3 | 1.147±0.148 | 1.009±0.145 | 1.018±0.155 | 16.9±7.0 | 50.8±6.4 | 23.1±1.3 |
| Aa | 155 | 30.1±6.0 | 173.0±6.4 | 70.8±11.1 | 23.6±3.4 | 1.137±0.131 | 0.997±0.127 | 1.017±0.132 | 16.1±6.8 | 51.2±5.4 | 22.1±0.6 |
| aa | 209 | 30.5±6.2 | 173.1±5.6 | 70.7±10.6 | 23.6±3.4 | 1.141±0.141 | 0.995±0.152 | 1.015±0.140 | 15.6±7.1 | 51.4±5.6 | 21.4±0.5 |
| P | 0.678 | 0.64 | 0.992 | 0.83 | 0.893 | 0.938 | 0.964 | 0.574 | 0.823 | 0.383 | |
| FokI | |||||||||||
| FF | 107 | 30.2±6.4 | 172.4±5.5 | 71.0±10.5 | 23.9±3.2 | 1.127±0.132 | 0.989±0.131 | 1.002±0.129 | 16.4±6.6 | 50.7±5.4 | 22.5±6.6 |
| Ff | 204 | 30.1±6.1 | 172.9±6.0 | 70.8±11.2 | 23.7±3.4 | 1.148±0.132 | 1.006±0.140 | 1.025±0.135 | 16.2±6.8 | 51.2±5.7 | 22.2±7.0 |
| ff | 89 | 30.6±5.8 | 173.7±6.3 | 70.2±10.5 | 23.3±3.3 | 1.137±0.156 | 0.986±0.160 | 1.013±0.153 | 14.8±7.5 | 52.1±5.6 | 20.1±8.2 |
| P | 0.855 | 0.311 | 0.855 | 0.419 | 0.425 | 0.415 | 0.174 | 0.243 | 0.224 | 0.054 | |
| CDX2 | |||||||||||
| AA | 103 | 29.8±6.5 | 172.4±5.7 | 72.9±10.4 | 24.5±3.2c | 1.143±0.125 | 1.004±0.143 | 1.017±0.130 | 18.0±6.6cf | 51.7±5.2 | 24.0±6.6cf |
| AG | 180 | 30.2±5.8 | 173.1±6.2 | 69.7±11.7 | 23.3±3.6 | 1.129±0.144 | 0.995±0.147 | 1.014±0.144 | 15.1±7.4 | 51.1±6.1 | 20.9±7.6 |
| GG | 117 | 30.8±6.2 | 173.2±5.7 | 70.3±9.6 | 23.4±3.0 | 1.154±0.137 | 0.994±0.134 | 1.019±0.135 | 15.4±6.1 | 51.2±5.1 | 21.3±6.8 |
| P | 0.496 | 0.579 | 0.053 | 0.006 | 0.287 | 0.879 | 0.445 | 0.004 | 0.712 | 0.002 | |