Table 5. Association of the two SNPs of ESR1 gene with phenotypic values in sons from one offsping (mean±SD, n=400). Values for BMD are raw values (means±SD); P values are results of analysis of variance (ANOVA) test for the least square mean of BMD among various genotypes after adjusting for significant covariates of age, weight, and height. P values are results of ANOVA test for the lease square mean of BMI, fat mass, lean mass among various genotypes after adjusting for significant covariates of age. Bold indicates significant P values (P<0.05). bP<0.05 vs pp genotype, cP<0.01 vs pp genotype. eP<0.05, fP<0.01 vs 2.
| Geno-type | n | Age (years) | Height (cm) | Weight (kg) | BMI | Lumber spine BMD (g/cm2) | Femoral neck BMD (g/cm2) | Total hip BMD (g/cm2) | Fat mass (kg) | Lean mass (kg) | PFM (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PvuII | |||||||||||
| PP | 46 | 30.9±6.5 | 171.8±5.9 | 69.5±10.3 | 23.5±3.1 | 1.175±0.129c | 1.019±0.150 | 1.041±0.151b | 15.5±6.8 | 50.9±5.2 | 21.4±6.6 |
| Pp | 189 | 30.2±6.2 | 173.4±6.0 | 69.9±10.6 | 23.3±3.4 | 1.143±0.136 | 0.997±0.139 | 1.016±0.133 | 15.0±7.0c | 51.0±5.4 | 21.0±7.6c |
| pp | 165 | 30.1±5.9 | 172.7±5.9 | 71.9±11.2 | 24.1±3.4 | 1.126±0.140 | 0.991±0.143 | 1.009±0.139 | 17.1±6.8 | 51.6±6.0 | 23.1±7.0 |
| P | 0.752 | 0.209 | 0.158 | 0.057 | 0.010 | 0.073 | 0.049 | 0.022 | 0.620 | 0.020 | |
| XbaI | |||||||||||
| XX | 15 | 28.3±5.6 | 174.0±6.6 | 70.7±11.6 | 23.3±3.4 | 1.200±0.153 | 1.043±0.210 | 1.024±0.170 | 16.1±8.5 | 51.3±4.7 | 21.6±8.5 |
| Xx | 134 | 30.9±6.0 | 173.0±5.2 | 71.1±10.3 | 23.7±3.2 | 1.145±0.137 | 0.990±0.142 | 1.021±0.140 | 15.9±6.7 | 51.3±5.0 | 21.9±7.1 |
| xx | 251 | 30.0±6.2 | 172.8±6.3 | 70.5±11.1 | 23.6±3.4 | 1.134±0.136 | 0.998±0.138 | 1.013±0.135 | 15.9±7.0 | 51.2±6.0 | 21.9±7.1 |
| P | 0.166 | 0.729 | 0.891 | 0.936 | 0.201 | 0.633 | 0.667 | 0.983 | 0.969 | 0.997 | |
| Haplotype containing px | |||||||||||
| none | 43 | 30.8±6.3 | 172.0±6 | 69.9±10.5 | 23.6±3.1 | 1.176±0.130f | 1.012±0.146 | 1.036±0.148e | 15.6±6.9 | 51.4±4.9 | 21.4±6.8 |
| 1 | 221 | 30.6±6.7 | 173.3±6.1 | 70.8±11.0 | 23.6±3.4 | 1.145±0.135 | 0.997±0.144 | 1.021±0.140 | 15.7±7.3 | 51.4±5.7 | 21.4±7.5 |
| 2 | 146 | 29.9±5.9 | 172.8±5.9 | 71.8±11.2 | 24.0±3.5 | 1.123±0.141 | 0.990±0.142 | 1.006±0.136 | 17±6.9 | 51.6±6.1 | 22.9±6.9 |
| P | 0.514 | 0.4 | 0.558 | 0.427 | 0.011 | 0.159 | 0.048 | 0.229 | 0.962 | 0.176 | |