Figure 5.
Effect of varying the longitudinal resistance of the interstitial space (Rol2) between the 5 parallel chains on propagation of APs simulated by PSpice in the 5 × 5 model. All other parameters held at their standard values (e.g., Rjc = 25 MΩ). Stimulation applied to cell A1. A: Rol2 = 100 KΩ (standard). B: Rol2 = 1.0 MΩ. C: Rol2 = 10 MΩ. D: Rol2 = 10 KΩ. Failure occurred at the border between C-chain and D-Chain. Propagation over the 25-cell network was fastest in C (TPT = 2.6 ms) and slowest in A (TPT = 6.5 ms). Propagation in the stimulated A-chain was unaffected by changing Rol2.