Figure 1.

Schema of treatment regimen. Fosaprepitant, 5-HT₃RA (FEC, AC: palonosetron 0.75 mg/body, (R-)CHOP: granisetron 3 mg/body), and/or dexamethasone 9.9 mg/body were administered to patients (fosaprepitant group), while only 5-HT₃RA (FEC, AC: palonosetron 0.75 mg/body, (R-)CHOP: granisetron 3 mg/body) and/or dexamethasone 9.9 mg/body were administered to the control group via peripheral venous route for premedication of a particular chemotherapy (AC, FEC or (R-)CHOP). fAPR, fosaprepitant; NS, normal saline; 5-HT₃RA, 5-hydroxytryptamine-3 receptor antagonist; DEX, dexamethasone; EPI, epirubicin; DXR, doxorubicin; VCR, vincristine; iv, intravenous injection; CPA, cyclophosphamide; and 5-FU, 5-fluorouracil.