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Crystal structures for key compounds derived from ZT0451. (A) X-ray structures of ZT0451 (magenta) and ZT1595 (cyan). Inset showing a rotation of the core to accommodate the R-group at the specificity pocket. (B) Original fragment hit ZT0451 and modifications at the nitro-group which is pointing towards the specificity pocket in PDE10. Four analogues showing significant increase in potency are summarized.
