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Comparison of “true” WT SHP2 structure (gray) with previously determined “WT” structure (PDB accession code: 2SHP). Note that the earlier structure has three mutations (T2K, F41L and F513S, presented in red sticks) and also contains a molecule of the detergent CTAB, (presented as red sticks and transparent sphere). The F513S mutation creates a cavity that binds the detergent molecule, which alters the orientation of the αF helix.
