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Superimposition of the Y279C mutant and WT SHP2 (grey) structures. In WT SHP2, Tyr279 lies in proximity to Cys459 and also interacts with Tyr62 of the N-SH2 domain (shown in blue and dark grey, respectively). Mutation from Tyr to Cys decreases these interactions. The P-loop (458–464) and pTyr loop (277–288) are highlighted in magenta and yellow, respectively.
