Table 3.
Changes in transcriptional level of Na v s in injured (L5) and non-injured (L4) DRG after SNL
| % of modification (SNL/sham) | p-values of treatment (SNL) for each DRG | Overall p-value of treatment (SNL) | |||
|---|---|---|---|---|---|
| DRGs |
L5 |
L4 |
L5 |
L4 |
|
| Nav1.1 |
-61% |
-33% |
** |
* |
p < 0.001 |
| Nav1.2 |
-19% |
-36% |
ns |
ns |
p = 0.013 |
| Nav1.3 |
+14% |
-23% |
ns |
ns |
p = 0.923 |
| Nav1.6 |
-63% |
-18% |
** |
ns |
p = 0.004 |
| Nav1.7 |
-53% |
-15% |
* |
ns |
p = 0.015 |
| Nav1.8 |
-74% |
+8% |
*** |
ns |
p = 0.003 |
| Nav1.9 | -78% | -17% | *** | ns | p = 0.002 |
% of change of Navs transcript in SNL as compared to sham in injured L5 and non-injured L4 DRG. 2–way ANOVA with independent measures to test for overall treatment effect and post hoc Bonferroni to test for statistical significance of treatment in each DRG (*p < 0.05, **p < 0.01 and ***p < 0.001).