Table 4.
Changes in transcriptional levels of Na v s in L3, L4 and L5 DRG after SNI
| % of modification (SNI/sham) | p-values of treatment (SNI) for each DRG | Overall p-value of treatment (SNI) | |||||
|---|---|---|---|---|---|---|---|
| DRG |
L3 |
L4 |
L5 |
L3 |
L4 |
L5 |
|
| Nav1.1 |
-43% |
-52% |
-9% |
* |
* |
ns |
p = 0.002 |
| Nav1.2 |
-30% |
-34% |
-34% |
ns |
ns |
ns |
p = 0.112 |
| Nav1.3 |
-27% |
-9% |
-38% |
ns |
ns |
ns |
p = 0.113 |
| Nav1.6 |
-32% |
-42% |
-11% |
ns |
ns |
ns |
p = 0.008 |
| Nav1.7 |
-35% |
-16% |
-16% |
** |
ns |
ns |
p < 0.001 |
| Nav1.8 |
-47% |
-49% |
-19% |
*** |
*** |
** |
p < 0.001 |
| Nav1.9 | -27% | -37% | -29% | * | * | * | p < 0.001 |
% of change of Navs transcript in SNI as compared to sham in L3, L4 and L5 DRG independently. 2–way ANOVA with independent measures to test for overall treatment effect and post hoc Bonferroni to test for statistical significance of treatment in each DRG (*p < 0.05, **p < 0.01 and ***p < 0.001).