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. 2014 Mar 7;11:45. doi: 10.1186/1742-2094-11-45

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Copyright © 2014 Belkouch et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ambroxol treatment blocks the changes in the biophysical properties of Na_v1.8 in large-sized DRG neurons extracted from rats 14 days post-CFA. (A) I-V curves of Na_v1.8 currents obtained from sham and inflamed large sensory neurons. (B) Histogram showing the effects of different concentrations of ambroxol (20 and 100 μM) on the increased Na_v1.8 peak current induced by CFA (***P <0.001, inflamed vs. sham large sensory neurons; ^###P <0.001 compared to inflamed DRG neurons; ANOVA followed by Sidak’s MCT; n = 6–13). (C) Ambroxol also significantly inhibits the leftward shift of the activation curves of Na_v1.8 current. Half-activation potential and slope factor are summarized in Additional file 3: Table S3. Note that the data corresponding to sham and day 14 after CFA treatment are the same as the ones in Figure 4.