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. 2014 Mar 7;11:45. doi: 10.1186/1742-2094-11-45

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Copyright © 2014 Belkouch et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of ambroxol on CFA-induced mechanical allodynia and edema. Mechanical sensitivity (A) and volume (B) of the ipsilateral hind paw are determined for sham animals and 14 days following CFA injection. Effects of ambroxol (0.3 mg/kg cumulative dose) were determined 1 h following administration of the last of 3 intrathecal injections (0.1 mg/kg injected on days 3, 8, and 14) on day 14 post-CFA. Data are expressed as mean ± SEM (6–8 rats/group). ***P <0.001, compared to sham. ^##P <0.01, ^###P <0.001 vs. CFA ipsilateral alone; One-way ANOVA followed by Sidak’s post-hoc comparisons test.