Methods |
Randomized trial; 2 parallel groups. |
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Unit of randomization: individual. |
Participants |
Dates of data collection: not reported. |
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Setting: Hopital Pellegrin, Bordeaux, France. |
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Inclusion criteria: women undergoing CS; both elective and non-elective deliveries |
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Exclusion criteria: allergy to beta-lactam antibiotics; pyrexia; indication for antibiotics |
Interventions |
Cefotetan 2 g after clamping of umbilical cord (N = 55) vs no antibiotic (N = 55) |
Outcomes |
Endometritis; urinary infection; local complications (classified as wound infection); fever only (cefotetan 0/55 vs control 6/55); antibiotic therapy (10/55 vs 25/55); mean days in hospital (10.0 vs 10.2, no variance given) |
Notes |
Translated from French. |
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Class of antibiotic: second generation cephalosporin (cefamycin) |
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Subgroups:
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Risk of bias |
Item |
Authors’ judgement |
Description |
Adequate sequence generation? |
Unclear |
“randomized.” |
Allocation concealment? |
Unclear |
Allocated by sealed envelopes. |
Blinding? |
Unclear |
Not placebo controlled. No additional information provided. |
All outcomes |
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Incomplete outcome data addressed? |
Unclear |
No losses or exclusions reported: analysis appears to be ITT |
All outcomes |
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Free of selective reporting? |
Unclear |
Insufficient information to judge. |
Free of other bias? |
Unclear |
There were no significant differences between the groups for risk factors for infection. There was insufficient other information which to judge |
Overall low risk of bias? |
Unclear |
Overall unclear. |