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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007482. doi: 10.1002/14651858.CD007482.pub2
Methods Randomized trial; 2 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: not reported.
Setting: Hopital Pellegrin, Bordeaux, France.
Inclusion criteria: women undergoing CS; both elective and non-elective deliveries
Exclusion criteria: allergy to beta-lactam antibiotics; pyrexia; indication for antibiotics
Interventions Cefotetan 2 g after clamping of umbilical cord (N = 55) vs no antibiotic (N = 55)
Outcomes Endometritis; urinary infection; local complications (classified as wound infection); fever only (cefotetan 0/55 vs control 6/55); antibiotic therapy (10/55 vs 25/55); mean days in hospital (10.0 vs 10.2, no variance given)
Notes Translated from French.
Class of antibiotic: second generation cephalosporin (cefamycin)
Subgroups:
  • both elective and non-elective CS - data could not be separate by type CS;

  • after cord clamping.

Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear “randomized.”
Allocation concealment? Unclear Allocated by sealed envelopes.
Blinding? Unclear Not placebo controlled. No additional information provided.
All outcomes
Incomplete outcome data addressed? Unclear No losses or exclusions reported: analysis appears to be ITT
All outcomes
Free of selective reporting? Unclear Insufficient information to judge.
Free of other bias? Unclear There were no significant differences between the groups for risk factors for infection. There was insufficient other information which to judge
Overall low risk of bias? Unclear Overall unclear.
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