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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007482. doi: 10.1002/14651858.CD007482.pub2
Methods RCT; 2 parallel groups.
Unit of randomization: individual.

Participants Dates of data collection: not reported.
Setting: University College Hospital, Ibadan, Nigeria. Majority of patients from low socioeconomic class
Inclusion criteria: both elective and non-elective cesarean deliveries
Exclusion criteria: fever or obvious infection before operation

Interventions Ampicillin 500 mg before operation and 250 mg 6 hourly for at least 7 days (IM until able to take orally) (N = 58) vs no antibiotics unless temperature 38 degrees C after the third post-operative day (N = 48). Both groups received curative doses of chloroquine

Outcomes Wound infection; UTI (not defined further); ’genital sepsis’ (not defined further: study group 5/58; control group 15/48)

Notes Prophylaxis continued for 7 days.
Class of antibiotic: Aminopenicillin (ampicillin).
Subgroups
  • both elective and non-elective CS - data could not be separated by type CS;

  • before cord clamping.


Risk of bias

Item Authors’ judgement Description

Adequate sequence generation? Unclear ‘Divided randomly into 2 groups.’
No additional details.

Allocation concealment? Unclear No information was provided.

Blinding? Unclear Not placebo-controlled.
All outcomes No additional details.

Incomplete outcome data addressed? Unclear No loss to follow up reported.
All outcomes No participants excluded; imbalance in group size not accounted for (58 vs 48)
ITT analysis.

Free of selective reporting? Unclear Insufficient information to judge.

Free of other bias? Unclear The 2 groups were comparable regarding age, parity and indications for CS

Overall low risk of bias? Unclear Very little information provided to assess risk of bias.
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