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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007482. doi: 10.1002/14651858.CD007482.pub2
Methods Randomized trial; 2 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: August 1979 and April 1980.
Setting: Universitats-Frauenklinik Wien, Austria.
Inclusion criteria: women undergoing CS.
Interventions IV metronidazole 500 mg before induction of anesthesia and 12 and 24 hours post-operatively, then rectal suppository × 4 days (N = 53) vs no treatment (N = 50)
Outcomes Fever (> 38°C on 2 subsequent days); wound infection; endometritis; additional use of antibiotics (treatment 13/53 vs control 22/50); maternal hospital days
Notes Full translation pending.
Class of antibiotic: Nitroimidazole (metronidazole).
Subgroups:
  • type of CS unclear;

  • before cord clamping.

Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear “…randomized…’ (no further details provided in translation)
Allocation concealment? Unclear No information provided.
Blinding? Unclear Not placebo-controlled.
All outcomes
Incomplete outcome data addressed? Yes No losses or exclusions were reported. It appears to be an ITT analysis
All outcomes
Free of selective reporting? Unclear Insufficient information to judge.
Free of other bias? Unclear Insufficient information to judge.
Overall low risk of bias? Unclear Mostly unclear.
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