Methods | Randomized trial; 2 parallel groups. | |
Unit of randomization: individual. | ||
Participants | Dates of data collection: August 1979 and April 1980. | |
Setting: Universitats-Frauenklinik Wien, Austria. | ||
Inclusion criteria: women undergoing CS. | ||
Interventions | IV metronidazole 500 mg before induction of anesthesia and 12 and 24 hours post-operatively, then rectal suppository × 4 days (N = 53) vs no treatment (N = 50) | |
Outcomes | Fever (> 38°C on 2 subsequent days); wound infection; endometritis; additional use of antibiotics (treatment 13/53 vs control 22/50); maternal hospital days | |
Notes | Full translation pending. | |
Class of antibiotic: Nitroimidazole (metronidazole). | ||
Subgroups:
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Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Unclear | “…randomized…’ (no further details provided in translation) |
Allocation concealment? | Unclear | No information provided. |
Blinding? | Unclear | Not placebo-controlled. |
All outcomes | ||
Incomplete outcome data addressed? | Yes | No losses or exclusions were reported. It appears to be an ITT analysis |
All outcomes | ||
Free of selective reporting? | Unclear | Insufficient information to judge. |
Free of other bias? | Unclear | Insufficient information to judge. |
Overall low risk of bias? | Unclear | Mostly unclear. |