Methods	Randomized, placebo-controlled trial; 2 parallel groups.
	Unit of randomization: individual.
Participants	Dates of data collection: July 1986-December 1987.
	Setting: Grenoble, France.
	Inclusion criteria: ‘low-risk’ women, undergoing CS (27% in labor)
	Exclusion: allergy to beta-lactam antibiotics, receipt of antibiotics within 3 days; ruptured membranes >12 hours; fever, amniotic infection
Interventions	Cefotetan 1 g IV at the time of cord clamping (N = 136) vs placebo injection (N = 130)
Outcomes	Endometritis, wound infection (includes superficial wound infection and deep abscess), septicaemia; additional antibiotic use (10/136 in treatment group vs 19/130 in placebo) ; antibiotic costs; maternal hospital stay
Notes	There was 1 episode of septicaemia in the placebo group.
	Class of antibiotic: second generation cephalosporin (cefamycin)
	Subgroups:
	type of CS unclear; after cord clamping.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	“…randomized by drawing of lots.”
Allocation concealment?	Unclear	No information provided.
Blinding?	Yes	Double blind, placebo-controlled.
All outcomes
Incomplete outcome data addressed?	Yes	No losses or exclusions were reported. Analysis appears to be ITT
All outcomes
Free of selective reporting?	Unclear	Insufficient information to judge.
Free of other bias?	Unclear	The 2 groups reported as comparable regarding demographic values. Insufficient additional information
Overall low risk of bias?	Unclear	Mostly unclear.