Methods	RCT; 2 parallel groups.
	Unit of randomization: individual.
Participants	Dates of data collection: June - September 1979.
	Setting: National Women’s Hospital, Auckland, New Zealand.
	Inclusion criteria: all women undergoing CS (8/73 were repeat)
	Exclusion: already on antibiotics.
Interventions	Metronidazole 500 mg IV prior to incision and metronidazole 2 g suppository at end of surgery (N = 35) vs matching placebo infusion and suppository (N = 38)
Outcomes	Fever (> 37.9°C within 14 days of delivery); wound infection, endometritis, UTI, major complication (return to theatre or hospitalised >10 days because of post-operative morbidity); need for antibiotic therapy (treatment 13 vs placebo 10); fever index (257 degree hours vs 165 hours)
Notes	1 major complication (not infectious) in each group (bleeding from lower segment in 1, major deep vein thrombosis extending into iliac veins in another)
	Drug class: nitroimidazole (metronidazole).
	Subgroups:
	type of CS unclear; before cord clamping.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	“Randomized.”
		No additional information.
Allocation concealment?	Unclear	No information was provided.
Blinding?	Yes	Double-blind, placebo-controlled.
All outcomes
Incomplete outcome data addressed?	Yes	No losses to follow up reported.
All outcomes		No participants excluded.
		ITT analysis.
Free of selective reporting?	Unclear	Insufficient information to judge.
Free of other bias?	Unclear	The groups were comparable regarding age and weight. There was insufficient other information which to judge
Overall low risk of bias?	Unclear	Mostly unclear.