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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007482. doi: 10.1002/14651858.CD007482.pub2
Methods Quasi-RCT; 5 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: not reported.
Setting: Bursa, Turkey..
Inclusion criteria: women undergoing CS due to acute fetal distress
Interventions Ceftriaxone 1 g (N = 25) vs mezlocillin 2 g (N = 23) vs clindamycin 600 mg and amikacin 500 mg (N = 18) vs sulbactam ampicillin 1 g (N = 25) IV after clamping of the cord vs no treatment (N = 28)
Outcomes Wound infection (redness, tenderness, pain and purulent discharge); UTI (renal angle tenderness, fever, dysuria and pyuria); endometritis (vaginal spotting, purulent discharge with fever and pain) plus positive cultures
Notes Treatment groups combined.
All wound infections were positive for coagulase negative staphylococcus
Class of antibiotic: third generation cephalosporin vs ureidopenicillin (mezlocillin) vs lincosamide (clindamycin) and aminoglycoside
Subgroups:
  • type of CS unclear;

  • after cord clamping.

Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? No “…according to the last digital of the patient’s file number…”
Allocation concealment? No “…according to the last digital of the patient’s file number…”
Blinding? Unclear Insufficient information provided.
All outcomes
Incomplete outcome data addressed? Yes No losses or exclusions were reported. It appeared to be an ITT analysis
All outcomes
Free of selective reporting? Unclear Insufficient information to judge.
Free of other bias? Unclear The 5 groups were comparable regarding maternal age, ruptured membranes, pelvic examinations, haemoglobin levels. Insufficient information to judge other aspects
Overall low risk of bias? No Quasi-RCT means it has high risk of bias.
HHS Vulnerability Disclosure