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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007482. doi: 10.1002/14651858.CD007482.pub2
Methods Randomized into 3 groups (irrigation vs systemic treatment vs no treatment)
Participants Dates of data collection: May 1988 - August 1989.
Setting: Beijing, China.
Inclusion criteria: women undergoing both elective (N = 112) and non-elective (N = 105) CS. Only women undergoing an elective CS were randomized to treatment or no treatment and have been included in analysis
Interventions Local irrigation with ampicillin 6 g after delivery of the placenta (N = 39) vs penicillin 5. 6 MU and gentamicin 240,000 U IV immediately after surgery and penicillin 1.6 MU and gentamicin 160,000 U per day IM × 3 days (N = 41) vs no treatment (N = 32). Treatment groups combined
Outcomes Endometritis (presence of any 2 of following: temperature above 37.5° C, uterine tenderness, foul vaginal discharge); abdominal wound infection (cellulitis with small amount ofexudate within 2 months ofoperation); uterine incision infection (associated with late postpartum haemorrhage); fever index
Notes Women undergoing non-elective sections randomized to either treatment group (not included in this review)
Class of antibiotic: Penicillin and aminoglycoside or aminopenicillin (ampicillin)
Subgroups:
  • elective CS;

  • after cord clamping.

Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear “… randomized…”
Allocation concealment? Unclear No information provided.
Blinding? Unclear No information provided.
All outcomes
Incomplete outcome data addressed? Unclear No losses or exclusions were reported. Analysis appears to be ITT
All outcomes
Free of selective reporting? Unclear Insufficient information to judge.
Free of other bias? Unclear Insufficient information to judge.
Overall low risk of bias? Unclear Mostly unclear.
HHS Vulnerability Disclosure