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. 2014 Mar 10;12:14. doi: 10.1186/1478-811X-12-14

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Copyright © 2014 Rinis et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of neutralizing gp130 Abs on signaling of CAgp130. T-REx-293-WTgp130-YFP (A) and T-REx-293-CAgp130-YFP (B) were left untreated or expression was induced with 20 ng/ml dox for the indicated periods of time. Cells were simultaneously incubated with indicated amounts of neutralizing gp130 Abs and subsequently stimulated with 200 U/ml IL-6 and 0.5 μg/ml sIL-6Rα or left unstimulated. TCLs were analyzed by immunoblotting using Abs against pStat3(Y705), Stat3, gp130 and actin as loading control.