Table 1. Potencies of nondepolarizing muscle relaxants at muscle nicotinic acetylcholine receptors in innervated and denervated skeletal muscles.

Antagonist	IC50 nmol/L (95% CI)		P value	IC50 ratios
	Innervation	Denervation
Vecuronium	11.2 (4.5–27.7)	39.2 (26.3–52.6)	<0.01	3.66±0.95
Atracurium	24.4 (10.5–32.7)	129.0 (81.0–152.7)	<0.01	5.52±1.48
Rocuronium	37.9 (23.3–61.3)	101.4 (82.2–123.6)	<0.01	2.82±0.46

Potencies of nondepolarizing muscle relaxants at nicotinic acetylcholine receptors are expressed as the value achieving 50% of maximal inhibition (IC₅₀) of the inward currents induced by coapplication of 30 μmol/L acetylcholine (95% confidence interval [CI]). Values are expressed as mean±SD in IC₅₀ ratios [IC₅₀ (denervation)/IC₅₀ (innervation)]. For the innervation group, denervation group, and IC₅₀ ratios, drug IC₅₀ values or ratios that do not share a superscript were statistically different from each other using one-way analysis of variance and Tukey's multiple comparison method. Potency differences between the denervation and innervation groups were compared for each drug using paired two-tailed Student's t-tests (P values).