Figure 4.

Effects of citalopram on deactivation kinetics of Kv1.5. (A) Tail currents were induced at the repolarizing pulses of −40 mV after a 250-ms depolarizing pulse of +50 mV from a holding potential of −80 mV in the absence and presence of 3 μmol/L citalopram. The dotted lines represent a zero current. Tail crossover phenomenon (indicated by the arrow) observed by superimposing the two tail currents. The solid lines over the current traces represent the single exponential fitting to the data. (B) Deactivation time constants (τ) obtained from (A). n=4, ^bP<0.05 vs control data. Data are expressed as mean±SEM.