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Rare Hypertension Resistance Variants were identified in NKCC2 and ROMK, which are essential for salt reabsorption in the thick ascending limb, and NCC, the thiazide sensitive transporter that is responsible for salt reabsorption in the distal convoluted tubule. Homozygous mutations in NKCC2 and ROMK cause Bartter's syndrome. Homozygous mutations in NCC cause Gitelman's syndrome. Carriers of these mutations are protected from hypertension.
