Table 3. Distribution of genotypes and alleles in patients with CHD and controls.
| ID | Gene | SNP rs ID (M>m) | Function | Population | Control |
CHD |
Pallele | Combined Pallele | Bonferroni | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MM/Mm/mm | MAF | MM/Mm/mm | MAF | ||||||||
| 1 | iNOS (G>A) | rs2297518 | Leu608Ser | First | 382/162/13 | 0.169 | 416/138/18 | 0.151 | 0.281 | 0.013 | 0.091 |
| Second | 346/144/12 | 0.167 | 394/98/15 | 0.126 | 0.009 | ||||||
| 2 | nNOS (G>A) | rs41279104 | promoter | First | 366/167/24 | 0.193 | 414/140/22 | 0.160 | 0.041 | 0.143 | |
| Second | 346/138/18 | 0.173 | 343/152/12 | 0.174 | 0.988 | ||||||
| 3 | eNOS (G>T) | rs1799983 | Glu298Asp | First | 446/102/9 | 0.108 | 461/107/8 | 0.107 | 0.946 | 0.451 | |
| Second | 398/99/5 | 0.109 | 419/81/7 | 0.094 | 0.268 | ||||||
| 4 | eNOS (T>C) | rs2020744 | promoter | First | 451/96/10 | 0.104 | 457/113/6 | 0.109 | 0.735 | 0.881 | |
| Second | 405/95/2 | 0.099 | 410/95/2 | 0.098 | 0.941 | ||||||
| 5 | CYBA (C>T) | rs1049255 | 3′-UTR | First | 188/261/108 | 0.428 | 229/264/83 | 0.373 | 0.008 | 0.001 | 0.007 |
| Second | 175/221/106 | 0.431 | 193/235/79 | 0.388 | 0.046 | ||||||
| 6 | CYBA (G>A) | rs4673 | Try72His | First | 471/85/1 | 0.078 | 492/83/1 | 0.074 | 0.698 | 0.538 | |
| Second | 426/74/2 | 0.078 | 436/70/1 | 0.071 | 0.567 | ||||||
| 7 | GCH1 (G>A) | rs841 | 3′-UTR | First | 267/234/56 | 0.311 | 236/253/87 | 0.373 | 0.003 | <0.001 | <0.001 |
| Second | 219/226/57 | 0.339 | 194/231/82 | 0.390 | 0.018 | ||||||
M: major allele; m: minor allele; MAF: minor allele frequency; Pallele: significance of minor allele frequency differences determined by χ2 tests, CHD vs control; Combined Pallele from two case-control populations were combined using Mantel-Haenszel test.